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Insecticides |
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Five reference laboratories were
established in Pakistan for monitoring
cholinesterase (ChE) activities of workers
exposed to organophosphorus compounds. ChE
activities were determined by the Michel and
tintometric method. Observations of ChE
activities were made during two malaria seasons.
The first season showed that although a
significant depression of cholinesterase
occurred among some of the workers, the ChE
activities of workers were within the normal
range during the following season. |
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The reason for the difference is
discussed. Similar studies were undertaken in
Haiti. Mean and standard deviations (SD) were
calculated for comparison of the tintometric
versus the Michel method. The data show a
correlation between the methods. For further
evaluation of the tintometric method,
organophosphorus and oxon analog inhibition of
cholinesterase were determined in vitro. The
tabulated data show that the tintometric method
is adequate for determining whether a worker is
exposed to dangerous amounts of insecticides. |
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